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Table 6 Logistic regression analysis of factors influencing recurrence at followed-up

From: Recurrence risk factors for chronic hepatitis B virus-infected patients who achieve functional cure with pegylated interferon-α-2b-based therapy: a multicenter pilot study

Characteristics

Univariate model

Multivariate model

OR (95% CI)

P value

OR (95% CI)

P value

Male gender

1.35 (0.45–4.04)

0.595

  

Age

0.99 (0.94–1.06)

0.955

  

Baseline HBsAg level

0.99 (0.99–1.02)

0.966

  

Treatment time

1.01 (0.99–1.03)

0.340

  

Consolidation time

0.96 (0.91–1.01)

0.097

0.92 (0.86–0.99)

0.017

Anti-HBs positive

0.32 (0.10-1.00)

0.049

0.13 (0.03–0.52)

0.004

IHC with PEG-IFN-α-2b monotherapy

1.00

   

CHB with PEG-IFN-α-2b add-on ETV therapy

0.30 (0.08–1.12)

0.073

  

CHB with PEG-IFN-α-2b add-on TDF therapy

0.62 (0.14–2.72)

0.522

  

CHB with PEG-IFN-α-2b add-on TAF therapy

0.58 (0.06–5.69)

0.636

  

CHB with PEG-IFN-α-2b add-on TMF therapy

< 0.01

0.999

  

Blood routine test

   White blood cells

1.52 (1.05–2.20)

0.029

  

   Neutrophils

2.12 (1.15–3.90)

0.016

  

   Platelets

1.01 (0.99–1.02)

0.183

  

   Red blood cells

3.13 (1.09–9.01)

0.034

  

   Hemoglobin

1.01 (0.98–1.03)

0.639

  

Liver function

   ALT

0.99 (0.96–1.02)

0.413

  

   AST

0.96 (0.90–1.02)

0.146

  

   T-BIL

1.06 (0.99–1.15)

0.106

  

   Total protein

0.93 (0.84–1.03)

0.147

  

   Albumin

0.90 (0.78–1.05)

0.183

  

   Globulin

0.94 (0.84–1.05)

0.270

  
  1. OR: odds ratio; 95% CI: 95% confidence interval; HBsAg: hepatitis B surface antigen; anti-HBs: hepatitis B surface antibody; IHC: inactive hepatitis B virus carrier; CHB: chronic hepatitis B; ETV: entecavir; TDF: tenofovir disoproxil fumarate; TAF: tenofovir alafenamide; TMF: tenofovir amibufenamide; ALT: alanine aminotransferase; AST: aspartate aminotransferase; T-BIL: total bilirubin