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Table 2 Cross hemagglutination Inhibition (HI) assay results comparing antigenicity of Recombinant H5N1 viruses with mutations at residues 90, 93, 110, 125, and 193

From: Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection

Immune serum

Geometric mean HI antibody titer

Antigen

21W_MVV

22W_MVV

22 W R90K

22W_KY

22 W A93T

22 W S125N

22 W N193D

21W_sera

1351.2

194.0*

111.4**

194.0*

168.9*

194.0*

1351.2

22W_sera

1351.2

1176.3

891.4

1351.2

891.4

1351.2

1176.3

Negative

< 1

< 1

< 1

< 1

< 1

< 1

< 1

  1. * Statistical significance of HI titers compared to those against 21W_MVV antigen (*p < 0.05, **p < 0.01). HI titer values were converted to log2, and statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparisons test
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Virology Journal

ISSN: 1743-422X