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Fig. 7 | Virology Journal

Fig. 7

From: Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction

Fig. 7

Cytokine-armed oncolytic virus remodel the intra-tumoral myeloid compartment. A Gating strategy. The single cell suspension was subjected to live dead staining and live CD45 cells were gated for further identifing and quantification the cell population of MHCII+ (M1) macrophages (B), MHCII− (M2) macrophages (C), cDCs(D), PMN-MDSCs (E), m-MDSCs (F), patrolling monocytes (G). The ratio of M1 to M2 macrophages (H) and the percentage of MHCII + subsets in CD11c + DCs(I), m-MDSCs (J) and patrolling monocytes (K) were also calculated. Data presented as the means ± SD. Statistical significance was calculated by one-way ANOVA followed by Bonferroni’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001

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Virology Journal

ISSN: 1743-422X