Study on the detection rate, genetic polymorphism, viral load, persistent infection capacity, and pathogenicity of human papillomavirus type 33

Table 4 Comparison of HPV33 E6/E7 allele frequencies

Prototype/mutation	Time 1	Time 2	p₁	Time 2.1	Time 2.2	p₂
E6prototype	126 (64.29%)	194 (74.05%)	0.024	92 (70.77%)	102 (77.27%)	0.230
A213C (K35N)	44 (22.45%)	57 (21.76%)	0.859	32 (24.62%)	25 (18.94%)	0.266
A364C (N86H)	21 (10.71%)	39 (14.89%)	0.191	17 (13.08%)	22 (16.67%)	0.414
A387C (K93N)	43 (21.94%)	51 (19.47%)	0.517	29 (22.31%)	22 (16.67%)	0.249
A446G (Q113R)	24 (12.24%)	41 (15.65%)	0.302	19 (14.62%)	22 (16.67%)	0.648
G542T (R145K)	22 (11.22%)	6 (2.29%)	< 0.001	4 (3.08%)	2 (1.52%)	0.398
E7prototype	123 (62.76%)	200 (76.34%)	0.002	96 (73.85%)	104 (78.79%)	0.347
C706T (A45V)	27 (13.78%)	11 (4.20%)	< 0.001	7 (5.38%)	4(3.03%)	0.342
C706A (A45E)	20 (10.20%)	10 (3.82%)	0.006	10 (7.69%)	0	0.001
A862T (Q87L)	24 (12.24%)	38 (14.50%)	0.484	16 (12.31%)	22 (16.67%)	0.316
**E6 + E7prototype**	98 (50.00%)	182 (69.47%)	< 0.001	86 (66.15%)	96 (72.73%)	0.248

Note The data with significant differences are in bold. E6 + E7 prototype indicates that both E6 and E7 on the same sequence are identical to the reference sequence. Time 1: January 1, 2009 to December 31, 2015. Time 2: January 1, 2017 to December 31, 2023. Time 2.1: January 1, 2017 to June 30, 2020. Time 2.2: July 1, 2020 to December 31, 2023. The “number (percentage)” represents number and percentage of HPV33 E6 or E7 prototype/mutation allele detected within the corresponding time period. p₁: The p-value of the comparison between time1 and time2. p₂: The p-value of the comparison between time 2.1 and time 2.2

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