Study on the detection rate, genetic polymorphism, viral load, persistent infection capacity, and pathogenicity of human papillomavirus type 33

Table 3 HPV33 E6 and E7 positive selection

Genes	Models	LnL	Estimates of parameters	2Δl and P	Positively selected sites
E6	M7	-797.193306	p = 0.00500, q = 0.02000		NA
	M8	-776.099507	p₀ = 0.95623, p = 43.03699, q = 99.00000, p1 = 0.04377, ω = 36.18486	42.2, p < 0.001	35 K, 86 N, 89E, 93 K, 113Q*
E7	M7	-479.935234	p = 0.00749, q = 0.00500		NA
	M8	-473.988826	p₀ = 0.92441, p = 0.03104, q = 0.02469, p1 = 0.07559, ω = 36.49653	11.9, p < 0.001	45 A, 93T, 97Q**

Note M7 means specifies the model of nucleotide substitution (REV); M8 means specifies the model of nucleotide substitution (UNREST). LnL: the log-likelihood difference between the two models. 2Δl: twice the log-likelihood difference between the two models (P < 0.05 was considered statistically significant). NA means not applicable. NS means no sites reached the significance level of Bayes empirical Bayes 0.90. An asterisk indicates posterior probability ≥ 0.95, and two asterisks indicate posterior probability ≥ 0.99

ISSN: 1743-422X