Fig. 1

The summary of the main metabolism pathways in DENV infected cells. glycolysis, TCA (Tricarboxylic acid) cycle, PPP (Pentose phosphate pathway), FAS (Fatty acid synthesis) and FAO (Fatty acid oxidation) and amino acid (Aa) metabolism. ACLY: ATP citrate lyase; ACO2: Aconitase 2; ATP: Adenosine triphosphate; CPT1: Carnitine palmitoyltransferase 1; CS: Citrate synthase; ENO: Enolase; FH: Fumarase; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; GLUT1: Glucose transporter 1; HK: Hexokinase; GS: Glutamine synthetase; IDH: Isocitrate dehydrogenase; IDO: Indoleamine 2,3-dioxygenase; LDHA: Lactate dehydrogenase; MCT1: Monocarboxylate transporter 1; MDH: Malate dehydrogenase; NO: Nitric oxide; iNOS: inducible NO synthase; OAA: Oxaloacetate; OGDH: α-ketoglutarate dehydrogenase; OXPHOS: Oxidative phosphorylation; P: Phosphate; PDH: Pyruvate dehydrogenase; PFK1: Phosphofructokinase 1; PGK1: Phosphoglycerate kinase 1; PGI: Phosphoglucoisomerase; PGM: Phosphoglycerate mutase; PKM: Pyruvate kinase muscle isotype; PP: bisphosphate; SAM: S-Adenosyl methionine; SCS: Succinyl coenzyme A synthetase; SDH: Succinate dehydrogenase; SLC: Solute carrier; TDO: Tryptophan 2,3-dioxygenase; TPI1: Triosephosphate isomerase 1. Reprinted with permission from ref [47]