Table 3 Secondary outcome. Death by COVID-19. Hepatitis B with or without cirrhosis. Death by covid vs non-hospitalized/hospitalized/ICU combined
From: Hepatitis B associated with severe COVID-19: a nationwide cohort study in Sweden
Dependent: Severity Death | Non-hosp./Hosp/ICU | Dead | OR (univariable) | OR (multivariable) | |
|---|---|---|---|---|---|
Hepatitis B | No hepatitis B | 836292 (98.6) | 11530 (1.4) | - | - |
Hepatitis B without cirrhosis | 2783 (99.2) | 22 (0.8) | 0.573 (0.365–0.849, p=0.009) | 1.003 (0.616–1.548, p=0.990) | |
Hepatitis B with cirrhosis | 90 (92.8) | 7 (7.2) | 5.641 (2.372–11.310, p<0.001) | 2.350 (0.921–5.203, p=0.050) | |
Age | Mean (SD) | 43.8 (16.6) | 83.1 (9.9) | 1.147 (1.145–1.149, p<0.001) | 1.133 (1.131–1.136, p<0.001) |
Sex | Women | 433583 (98.8) | 5266 (1.2) | - | - |
Men | 405582 (98.5) | 6293 (1.5) | 1.278 (1.231–1.326, p<0.001) | 2.353 (2.250–2.461, p<0.001) | |
Region of birth | Northern Europe | 645459 (98.5) | 10074 (1.5) | - | - |
Other Europe | 37119 (98.8) | 449 (1.2) | 0.775 (0.704–0.851, p<0.001) | 0.956 (0.856–1.066, p=0.424) | |
Africa | 17121 (99.4) | 110 (0.6) | 0.412 (0.339–0.494, p<0.001) | 1.336 (1.075–1.642, p=0.007) | |
Asia | 100738 (99.4) | 597 (0.6) | 0.380 (0.349–0.412, p<0.001) | 0.851 (0.768–0.942, p=0.002) | |
America | 11154 (99.3) | 81 (0.7) | 0.465 (0.371–0.575, p<0.001) | 0.966 (0.751–1.224, p=0.779) | |
Other/missing | 27574 (99.1) | 248 (0.9) | 0.576 (0.506–0.652, p<0.001) | 1.041 (0.901–1.198, p=0.579) | |
COVID-19 Vaccination | 0 | 830242 (98.7) | 11272 (1.3) | - | - |
1 | 8923 (96.9) | 287 (3.1) | 2.369 (2.099–2.663, p<0.001) | 0.598 (0.524–0.681, p<0.001) | |
wCCI group (excl liver disease) | 0 | 789545 (99.2) | 6585 (0.8) | - | - |
1–2 | 28458 (94.2) | 1748 (5.8) | 7.365 (6.975–7.772, p<0.001) | 2.022 (1.896–2.156, p<0.001) | |
3–4 | 6462 (80.8) | 1540 (19.2) | 28.574 (26.886–30.353, p<0.001) | 2.784 (2.589–2.992, p<0.001) | |
>=5 | 14700 (89.7) | 1686 (10.3) | 13.752 (13.000–14.539, p<0.001) | 3.008 (2.809–3.221, p<0.001) | |
Education | Tertiary | 323916 (99.4) | 1887 (0.6) | - | - |
Secondary | 366704 (98.9) | 4214 (1.1) | 1.973 (1.868–2.083, p<0.001) | 1.199 (1.128–1.276, p<0.001) | |
Primary | 129108 (96.2) | 5032 (3.8) | 6.690 (6.344–7.058, p<0.001) | 1.252 (1.175–1.335, p<0.001) | |
Missing | 19437 (97.9) | 426 (2.1) | 3.762 (3.379–4.179, p<0.001) | 1.641 (1.426–1.885, p<0.001) | |
Income | Highest | 174801 (99.5) | 892 (0.5) | - | - |
High | 175704 (99.6) | 680 (0.4) | 0.758 (0.686–0.838, p<0.001) | 1.089 (0.979–1.209, p=0.115) | |
Middle | 174092 (99.3) | 1220 (0.7) | 1.373 (1.260–1.498, p<0.001) | 1.480 (1.348–1.625, p<0.001) | |
Low | 166233 (97.4) | 4458 (2.6) | 5.255 (4.892–5.652, p<0.001) | 2.035 (1.877–2.209, p<0.001) | |
Lowest | 137646 (97.0) | 4293 (3.0) | 6.112 (5.688–6.575, p<0.001) | 2.372 (2.178–2.585, p<0.001) | |
Missing | 10689 (99.9) | 16 (0.1) | 0.293 (0.171–0.464, p<0.001) | 1.333 (0.757–2.184, p=0.285) |