Table 2 Primary outcome. Severe COVID-19. Hospitalization/ICU/death by COVID-19 combined vs non-hospitalized
From: Hepatitis B associated with severe COVID-19: a nationwide cohort study in Sweden
Dependent: Severity | Non-hospitalized, No (%) | Hospitalized/ICU/Dead No (%) | OR (univariable) | OR (multivariable) | |
|---|---|---|---|---|---|
Hepatitis B | No hepatitis B | 790349 (93.2) | 57473 (6.8) | - | - |
Hepatitis B | 2541 (87.6) | 361 (12.4) | 1.954 (1.746–2.179, p<0.001) | 1.242 (1.097–1.403, p=0.001) | |
Age | Mean (SD) | 42.7 (15.9) | 66.6 (18.0) | 1.080 (1.079–1.080, p<0.001) | 1.077 (1.076–1.077, p<0.001) |
Sex | Women | 413758 (94.3) | 25091 (5.7) | - | - |
Men | 379132 (92.1) | 32743 (7.9) | 1.424 (1.400–1.449, p<0.001) | 1.784 (1.750–1.820, p<0.001) | |
Region of birth | Northern Europe | 614466 (93.7) | 41067 (6.3) | - | - |
Other Europe | 34682 (92.3) | 2886 (7.7) | 1.245 (1.197–1.295, p<0.001) | 1.454 (1.390–1.521, p<0.001) | |
Africa | 15618 (90.6) | 1613 (9.4) | 1.545 (1.466–1.628, p<0.001) | 2.549 (2.402–2.703, p<0.001) | |
Asia | 92428 (91.2) | 8907 (8.8) | 1.442 (1.408–1.477, p<0.001) | 2.086 (2.026–2.148, p<0.001) | |
America | 10191 (90.7) | 1044 (9.3) | 1.533 (1.436–1.634, p<0.001) | 2.093 (1.949–2.245, p<0.001) | |
Other/missing | 25505 (91.7) | 2317 (8.3) | 1.359 (1.301–1.420, p<0.001) | 1.749 (1.665–1.837, p<0.001) | |
COVID-19 vaccination | 0 | 784573 (93.2) | 56941 (6.8) | - | - |
1 | 8317 (90.3) | 893 (9.7) | 1.479 (1.379–1.585, p<0.001) | 0.560 (0.518–0.606, p<0.001) | |
wCCI group (excl liver disease) | 0 | 752170 (94.5) | 43960 (5.5) | - | - |
1–2 | 24044 (79.6) | 6162 (20.4) | 4.385 (4.257–4.516, p<0.001) | 2.374 (2.290–2.461, p<0.001) | |
3–4 | 4687 (58.6) | 3315 (41.4) | 12.102 (11.563–12.664, p<0.001) | 2.604 (2.464–2.753, p<0.001) | |
>=5 | 11989 (73.2) | 4397 (26.8) | 6.275 (6.054–6.504, p<0.001) | 2.904 (2.775–3.038, p<0.001) | |
Education | Tertiary | 311056 (95.5) | 14747 (4.5) | - | - |
Secondary | 347544 (93.7) | 23374 (6.3) | 1.419 (1.389–1.449, p<0.001) | 1.150 (1.124–1.178, p<0.001) | |
Primary | 116476 (86.8) | 17664 (13.2) | 3.199 (3.126–3.273, p<0.001) | 1.315 (1.279–1.352, p<0.001) | |
Missing | 17814 (89.7) | 2049 (10.3) | 2.426 (2.310–2.546, p<0.001) | 1.519 (1.421–1.623, p<0.001) | |
Income | Highest | 167181 (95.2) | 8512 (4.8) | - | - |
High | 168963 (95.8) | 7421 (4.2) | 0.863 (0.836–0.891, p<0.001) | 1.092 (1.056–1.129, p<0.001) | |
Middle | 166740 (95.1) | 8572 (4.9) | 1.010 (0.979–1.041, p=0.538) | 1.292 (1.250–1.336, p<0.001) | |
Low | 154795 (90.7) | 15896 (9.3) | 2.017 (1.963–2.073, p<0.001) | 1.614 (1.565–1.665, p<0.001) | |
Lowest | 124968 (88.0) | 16971 (12.0) | 2.667 (2.596–2.740, p<0.001) | 1.904 (1.842–1.967, p<0.001) | |
Missing | 10243 (95.7) | 462 (4.3) | 0.886 (0.804–0.974, p=0.013) | 1.540 (1.377–1.718, p<0.001) |