Fig. 7
Pathogenicity and replication capacity of H4N1 avian influenza viruses in BALB/c mice. (a) Body weight change kinetics in mice inoculated with CS01, CS01-A4, CS01-A7, and PBS (control). (b) Virus titers in various mouse organs at 3 and 6 dpi. Tissue samples were weighed, and virus titers were determined by titration in MDCK cells, with results reported as TCID50 per 0.1 g of tissue. Data points represent the mean of three independent experiments. Statistical significance is denoted by the number of asterisks, with * indicating P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001