Fig. 1

Frequency distribution of nonsynonymous (N) and synonymous (S) mutations in SARS-CoV-2. (A) Frequency distribution of synonymous and nonsynonymous mutations. Dashed line represents average frequency of four-fold degenerate sites. (B) Correlation of synonymous (p < 10− 2, Kendall correlation, τ = 0.19) and (C) nonsynonymous (lower panel, p = 0.11, τ = 0.09) mutation frequency between hosts (X-axis) with number of intra-host variants (Y-axis) (see Materials and Methods)