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Fig. 4 | Virology Journal

Fig. 4

From: Cytomegalovirus infection initiates inflammatory bowel disease by activating a positive MyD88/NF-κB feedback loop in allogeneic skin transplantation mice

Fig. 4

Effect of hMIEP-eGFP K181 infection on the NF-κB signaling pathway in allogeneic skin transplantation mice. 1 × 105 PFU hMIEP-eGFP K181 or eGFP K181 were inoculated intranasally into allogeneic skin transplantation BALB/c mice on day 14 posttransplantation. The serum levels of (A) TNF-α, (B) IL-1β, (C) IL-6, (D) IL-8, and (E) IL-12 were measured by ELISA; (F) The expression levels of IKKα, IKKβ, p65, p52, TRIF, MyD88, TRAF6, and TAK1 in colon tissues were measured by Western blot at 5, 9, 14, or 21 d postinfection. Data are shown as the mean ± SD of six mice per group. * P < 0.05, *** P < 0.001 vs. eGFP K181

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Virology Journal

ISSN: 1743-422X