Transcriptomic profiles of Crandell-Rees feline kidney cells infected with Varicellovirus felidalpha-1 (FHV-1) field and vaccine strains

Table 3 The top 10 commonly up- and downregulated genes in CRFK cells inoculated with the field (384/75) or vaccine (Feligen) strain

Up regulated	Gene ID	Gene function	384/75		Vaccine
	Gene ID	Gene function	FDR¹	LFC²	FDR¹	LFC²
	H4C16	Histone	< 0.01	7.48	< 0.01	7.16
	H4C13	Histone	< 0.01	7.48	< 0.01	6.92
	H2BC3	Histone	< 0.01	7.32	< 0.01	7.32
	H3C11	Histone	< 0.01	7.21	< 0.01	7.80
	LOC123386069	–	< 0.01	7.20	< 0.01	7.80
	LOC111559230	–	< 0.01	6.98	< 0.01	8.68
	H3C6	Histone	0.01	6.86	< 0.01	6.94
	Histone H4	Histone	< 0.01	6.81	< 0.01	7.48
	Histone H4	Histone	< 0.01	6.78	< 0.01	6.62
	Histone H3.1	Histone	< 0.01	6.77	< 0.01	6.71
Down regulated	COL8A1	Cell homeostasis	< 0.01	-5.87	< 0.01	-5.63
	ATP6V0D2	Cell adhesion	< 0.01	-5.63	< 0.01	-4.00
	ADAMDEC1	Cell migration	0.03	-5.22	0.01	-4.37
	FGF7	Growth factor	0.01	-5.13	< 0.01	-5.72
	VCAM1	Cell surface receptor	0.00	-5.13	< 0.01	-6.10
	SCARA5	Pattern recognition receptor	0.04	-5.11	0.01	-5.54
	REG4	Cell homeostasis	0.01	-5.06	< 0.01	-4.73
	CB1H4orf36	–	0.02	-4.63	0.01	-2.20
	MHC class II	Cell surface receptor	0.01	-4.58	< 0.01	-2.17
	TMEM100	Cell homeostasis	< 0.01	-4.56	< 0.01	-5.14

¹ The false discovery rate (FDR) is shown
² P-values < 0.05 with LFC > 2 for upregulated or < -2 for downregulated genes were considered significant
The functions of characterised genes are shown alongside the gene expression levels, which are represented by log₂ fold change (LFC), ordered by expression in field infection samples

ISSN: 1743-422X