Table 2 Characteristics of different tissues infection in E30/A538-infected ICR suckling mice treated with IFN
From: Establishment and application of a wild neonatal mouse model infected with an Echovirus 30 isolate
Tissue | ①E30 treated | ②-③ IFN-α2a + E30 treated | Severity of lesions | |
|---|---|---|---|---|
①Clinical score = 5 | ② Clinical score = 2 | ③ Clinical score = 5 | compare | |
Brain | Extensive lymphocytic infiltration | Lymphocytic infiltration | Lymphocytic infiltration | â‘ >â‘¢>â‘¡ |
Heart | A large area of severe myocardial necrolysis | Scattered lymphocytes | A small area of severe myocardial necrolysis | â‘ >â‘¢>â‘¡ |
Spinal cord | Lymphocytic infiltration | Lymphocytic infiltration | Lymphocytic infiltration | â‘ >â‘¢>â‘¡ |
Fat | Fat necrosis and calcification | No changes | Fat necrosis and calcification | â‘ >â‘¢>â‘¡ |
Limb Muscle | Scattered lymphocytes | No changes | Scattered lymphocytes | â‘ >â‘¢>â‘¡ |
Liver | Mild edema of hepatocytes | No changes | Mild edema of hepatocytes | â‘ >â‘¢>â‘¡ |