Table 1 Antiviral activity of BPPT
Compounds | Virus | Cells | Assay | EC50a (1:5 dilution) (μmol/L) | CC50b (1:5 dilution) (μmol/L) | SIc |
|---|---|---|---|---|---|---|
BPPT | NL4-3 (X4) | TZM-bl | Luc | 0.06 ± 0.01 | > 50 | > 833 |
A3.01 | p24 | 0.16 ± 0.02 | > 50 | > 313 | ||
JRCSF (R5) | TZM-bl | Luc | 0.16 ± 0.01 | > 50 | > 313 | |
89.6 (X4/R5) | TZM-bl | Luc | 0.09 ± 0.00 | > 50 | > 556 | |
NL4-3 (X4) | PBMCs | p24 | 0.08 ± 0.01 | > 50 | > 625 | |
JRCSF (R5) | PBMCs | p24 | 0.04 ± 0.03 | > 50 | > 1,250 | |
EFV | NL4-3 (X4) | TZM-bl | Luc | 0.001 ± 0.00 | 25.87 | 25,870 |
NVP | 0.08 ± 0.18 | > 50 | > 625 |