Table 1 Gene family analysis of NTD-targeting infection-enhancing antibodies
mAbs | Heavy chain | Light chain | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
VH Gene | DH Gene | JH Gene | CDR3 (amino acids) | CDR3 length | % SHM | VL Gene | JL Gene | CDR3 (amino acids) | CDR3 length | % SHM | |
P5S-1D12 | IGHV1-24 | IGHD3-3 | IGHJ2 | ATGSGYSSHWNWYFDL | 16 | 0 | IGKV1D-16 | IGKJ4 | QQYNSYPLT | 9 | 0 |
DH1052* | IGHV1-69 | IGHD2-21 | IGHJ4 | ATSSGPSRLCGGGSCYHSFDY | 21 | 0 | IGKV3-20 | IGKJ1 | QQYGSSPTWT | 10 | 0 |
P10S-1A10 | IGHV1-69 | IGHD2-15 | IGHJ6 | AREGVVVAAATPLYGMDV | 18 | 0.7 | IGKV2D-29 | IGKJ2 | MQSIHLPYT | 9 | 0.7 |
8D2* | IGHV3-7 | IGHD3-9 | IGHJ3 | ARDWDYDILTGSWFGAFDI | 19 | 1.4 | IGKV1-17 | IGKJ4 | LQHNSYPLT | 9 | 0 |
COV2-2490* | IGHV3-7 | IGHD3-3 | IGHJ4 | ARDPYDLYGDYGGTFDY | 17 | 2.7 | IGKV1-5 | IGKJ4 | QQYNSYSLT | 9 | 1.1 |
P5-1H4 | IGHV3-7 | IGHD2-15 | IGHJ4 | ARDLTEAYCSGGGCSEGFDY | 20 | 2.8 | IGKV1-5 | IGKJ2 | QQYHSYPVT | 9 | 1.8 |
COV2-2369* | IGHV3-30 | IGHD5-18 | IGHJ4 | AKDFGGDNTAMVEYFFDF | 18 | 2.4 | IGKV1-5 | IGKJ1 | QQYNSYSPT | 9 | 0 |
P5-1B4 | IGHV3-33 | IGHD4-17 | IGHJ4 | AKDFGNDYGDIGGNFDY | 17 | 2.4 | IGKV1-16 | IGKJ4 | QQYHSYPLT | 9 | 0.7 |
P10S-1D9 | IGHV3-43 | IGHD3-10 | IGHJ6 | AKDLGSYNYYYGMDV | 15 | 1.7 | IGKV3-11 | IGKJ4 | QQRSNWPLT | 9 | 0 |
P10S-2E8 | IGHV3-48 | IGHD3-22 | IGHJ5 | ARDLFSNYYDSSGYYVFNWFDP | 22 | 0.3 | IGKV1-9 | IGKJ4 | QQLNSYPPT | 9 | 0 |
P5S-2A8 | IGHV4-30 | IGHD3-22 | IGHJ4 | ARGHYSYDNSGTFDY | 15 | 2.1 | IGKV1-17 | IGKJ4 | LQHNTYPLT | 9 | 0.7 |
P2S-2A5 | IGHV4-39 | IGHD2-15 | IGHJ6 | ARDRDSAGSRIMGGMDV | 17 | 0.3 | IGKV1-12 | IGKJ3 | QQANSFPFT | 9 | 0 |
P5S-1B7 | IGHV4-59 | IGHD2-15 | IGHJ4 | AKGDVESCSGGSCYYFDF | 18 | 2.8 | IGKV3-20 | IGKJ3 | QHYGGSPLFT | 10 | 2.5 |