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Fig. 1 | Virology Journal

Fig. 1

From: NIEAs elicited by wild-type SARS-CoV-2 primary infection fail to enhance the infectivity of Omicron variants

Fig. 1

Enhancement activity and binding capacity of 9 NTD-targeting infection-enhancing antibodies (NIEAs). The infection-enhancing activity (a) and binding capacity (b) of P2S-2A5, P5-1B4, P5S-1B7, P5-1H4, P5S-2A8, P10S-1A10, P10S-1D9, P10S-2E8, and P5S-1D12 were measured by the pseudovirus infection assay and flow cytometry analysis. COV2-2490, COV2-2369, 8D2, and DH1052 were published NIEAs as positive controls. SA55 (anti-SARS-CoV-2 RBD), 76E1 (anti-SARS-CoV-2 S2), and VRC01 (anti-HIV-1) were non-NIEAs as negative controls. The infection-enhancing activity of IgG-, F(ab’)2, and Fab-form P10S-1D9 were measured using HEK293T-hACE2 cells (c) and Huh7 cells (d). The experiments were performed twice and one representative result was shown

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Virology Journal

ISSN: 1743-422X