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Fig. 5 | Virology Journal

Fig. 5

From: Long-term inhibition of Hepatitis B virus gene expression by a primary microrna expressing ancestral adeno-associated viral vector

Fig. 5

Measurement of pro-inflammatory response in scAnc80 infected mice. Cytokine quantification was performed 6 h after injection with scAAVs, saline or poly (I: C). Cytometric bead array assay quantification of serum cytokines from 6 mice per group: (a) IL-12p70, (b) IFN- γ, (c) IL-10, (d) IL-6, (e) MCP-1 and (f) TNF-α. Concentrations of (g) IFIT-1, (h) IFN-β, (i) and OAS-1 mRNAs in liver samples from 4 mice per group determined using RT-qPCR. The means (± SEM) were derived from six or four mice per group. The Student’s two-tailed paired t-test was used to ascertain statistically significant differences relative to the saline control. pvalues < 0.05 (*), < 0.001 (**), < 0.0001 (***) were regarded as statistically significant and pvalues ≥ 0.05 were regarded as statistically insignificant (NS)

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Virology Journal

ISSN: 1743-422X