Fig. 4
From: IL-37 attenuated HPV induced inflammation of oral epithelial cells via inhibiting PI3K/AKT/mTOR
AKT is involved in that IL37 attenuated HPV induced inflammation on oral epithelial cells. A IL37 dose dependently reduced expression of AKT on HOEC cells; B IL37 dose dependently reduced expression of AKT on IMP-H026 cells; C AKT KD compromised effects of IL37 on increase of IL18 induced by HPV on HOEC cell line; D AKT KD compromised effects of IL37 on increase of IL8 induced by HPV on HOEC cell line; E AKT KD compromised effects of IL37 on increase of TNFɑ induced by HPV on HOEC cell line; F AKT KD compromised effects of IL37 on increase of IL18 induced by HPV on IMP-H026 cell line; G AKT KD compromised effects of IL37 on increase of IL8 induced by HPV on IMP-H026 cell line; H AKT KD compromised effects of IL37 on increase of TNFɑ induced by HPV on IMP-H026 cell line