Fig. 3
From: IL-37 attenuated HPV induced inflammation of oral epithelial cells via inhibiting PI3K/AKT/mTOR
PI3K is involved in that IL37 attenuated HPV induced inflammation on oral epithelial cells. A IL37 dose dependently reduced expression of PI3K on HOEC cells; B IL37 dose dependently reduced expression of PI3K on IMP-H026 cells; C PI3K KD compromised effects of IL37 on increase of IL18 induced by HPV on HOEC cell line; D PI3K KD compromised effects of IL37 on increase of IL8 induced by HPV on HOEC cell line; E PI3K KD compromised effects of IL37 on increase of TNFɑ induced by HPV on HOEC cell line; F PI3K KD compromised effects of IL37 on increase of IL18 induced by HPV on IMP-H026 cell line; G PI3K KD compromised effects of IL37 on increase of IL8 induced by HPV on IMP-H026 cell line; H PI3K KD compromised effects of IL37 on increase of TNFɑ induced by HPV on IMP-H026 cell line