Skip to main content

Table 4 Association of HLA alleles and progression of HTLV infection to HAM/TSP

From: The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis

 

#study

HAM/TSP

AC

OR

95% CI

z

P

I2 (%)

P-het

P-egger

A*01

4

40/480

34/404

0.92

0.56–1.5

 − 0.35

0.72

0.00

0.41

0.94

A*02

15

681/2101

985/2547

0.81

0.6–1.1

 − 1.33

0.18

76.12

 < 0.01

0.26

A*03

5

77/598

81/784

1.17

0.82–1.66

0.86

0.39

0.00

0.79

0.46

A*11

4

175/1014

165/1125

1.23

0.98–1.56

1.76

0.08

0.00

0.44

0.59

A*23

3

54/445

71/628

0.96

0.55–1.68

 − 0.14

0.89

40.64

0.18

0.82

A*24

8

619/1183

691/1275

1.11

0.93–1.33

1.15

0.25

0.00

0.90

0.34

A*26

3

213/1009

254/1121

0.97

0.77–1.23

 − 0.22

0.82

7.02

0.34

0.67

A*28

2

25/122

8/87

2.59

1.09–6.11

2.18

0.03

0.00

0.85

 < 0.01

A*29

2

19/327

19/248

0.75

0.39–1.45

 − 0.86

0.39

0.00

0.81

 < 0.01

A*30

6

59/662

112/874

0.60

0.41–0.85

 − 2.85

0.01

0.00

0.79

0.91

A*31

3

46/363

38/321

1.12

0.64–1.95

0.40

0.68

17.17

0.29

0.03

A*32

2

14/215

9/169

2.15

0.22–21.04

0.66

0.51

55.18

0.13

 < 0.01

A*33

5

113/1244

153/1584

0.90

0.66–1.22

 − 0.70

0.49

15.81

0.31

0.67

A*34

2

7/328

27/545

0.48

0.2–1.16

 − 1.63

0.10

0.00

0.87

 < 0.01

A*36

2

12/327

11/248

0.79

0.34–1.83

 − 0.56

0.58

0.00

0.65

 < 0.01

A*68

2

72/328

69/545

1.66

0.94–2.94

1.74

0.08

50.60

0.15

 < 0.01

A*74

3

27/445

53/628

0.62

0.37–1.03

 − 1.83

0.07

0.00

0.82

0.98

B*07

8

213/1270

160/1700

1.54

0.89–2.67

1.55

0.12

68.34

0.00

0.47

B*13

2

6/358

7/317

0.79

0.26–2.4

 − 0.41

0.68

0.00

0.55

 < 0.01

B*14

2

13/215

12/169

1.05

0.23–4.72

0.06

0.95

31.70

0.22

 < 0.01

B*15

4

77/593

114/780

0.83

0.58–1.19

 − 0.99

0.31

20.11

0.28

0.54

B*18

3

17/363

10/321

1.36

0.62–3.01

0.76

0.45

0.00

0.62

0.80

B*27

2

10/358

5/317

1.51

0.52–4.37

0.75

0.45

0.00

0.39

 < 0.01

B*35

5

183/1244

235/1584

0.96

0.65–1.41

 − 0.23

0.82

63.12

0.02

0.55

B*37

2

0/358

8/317

0.10

0.01–0.79

 − 2.18

0.03

0.00

0.72

 < 0.01

B*39

3

34/1009

56/1121

0.69

0.44–1.08

 − 1.63

0.10

0.00

0.49

0.02

B*40

3

102/1009

191/1121

0.50

0.37–0.65

 − 5.01

0.01

38.53

0.19

0.33

B*42

3

26/445

39/628

0.85

0.49–1.47

 − 0.59

0.56

0.00

0.49

0.46

B*44

5

57/598

94/784

0.64

0.44–0.92

 − 2.41

0.02

0.00

0.52

0.19

B*45

2

23/475

10/400

1.76

0.81–3.83

1.44

0.15

0.00

0.86

 < 0.01

B*46

2

87/799

98/956

1.06

0.78–1.44

0.40

0.69

0.00

0.92

 < 0.01

B*48

3

32/1009

39/1121

0.92

0.57–1.48

 − 0.36

0.72

0.00

0.67

0.82

B*51

3

167/1009

168/1121

1.15

0.89–1.49

1.07

0.28

7.70

0.33

0.51

B*52

4

185/1021

225/1128

0.99

0.59–1.68

 − 0.02

0.98

51.96

0.10

0.37

B*53

3

59/445

87/628

0.92

0.62–1.35

 − 0.45

0.65

96.00

0.36

0.83

B*54

2

97/381

50/354

1.97

1.17–3.30

2.56

0.01

45.40

0.17

 < 0.001

B*55

3

53/1009

63/1121

0.82

0.37–1.81

 − 0.49

0.63

50.98

0.13

0.03

B*56

3

16/1009

15/1121

1.26

0.63–2.56

0.65

0.51

0.00

0.91

0.70

B*57

3

30/445

47/628

0.79

0.48–1.28

 − 0.96

0.34

0.00

0.49

0.90

B*58

4

38/593

49/780

0.98

0.62–1.55

 − 0.08

0.93

0.00

0.60

0.19

B*59

2

39/799

40/956

1.13

0.65–1.96

0.42

0.68

20.20

0.26

 < 0.01

C*01

3

342/1009

364/1121

1.20

1–1.46

1.90

0.06

0.00

0.75

0.04

C*02

2

23/358

30/317

0.62

0.23–1.67

 − 0.95

0.34

12.10

0.28

 < 0.01

C*04

3

96/1009

132/1121

0.67

0.39–1.15

 − 1.45

0.15

67.37

0.04

0.82

C*05

2

14/358

10/317

1.14

0.49–2.61

0.30

0.77

0.00

0.44

 < 0.01

C*06

2

28/358

31/317

0.70

0.41–1.22

 − 1.24

0.21

0.00

0.48

 < 0.01

C*07

4

303/1018

252/1205

1.69

1.15–2.46

2.69

0.01

57.61

0.06

0.56

C*08

9

76/759

132/819

0.58

0.41–0.79

 − 3.34

0.01

28.23

0.18

0.46

C*12

3

189/1009

242/1121

0.88

0.71–1.1

 − 1.13

0.26

0.00

0.56

0.76

C*14

3

197/1009

226/1121

1.04

0.84–1.29

0.34

0.73

0.00

0.94

0.02

C*15

3

37/1009

54/1121

0.75

0.49–1.15

 − 1.34

0.18

0.00

0.86

0.83

DQB1*02

3

91/289

134/506

1.00

0.62–1.61

0.01

0.99

44.66

0.16

0.71

DQB1*02:01

2

52/172

98/423

1.22

0.8–1.86

0.92

0.36

0.00

0.40

 < 0.01

DQB1*03

4

495/940

602/1310

1.08

0.9–1.29

0.80

0.42

0.00

0.55

0.22

DQB1*03:01

2

51/172

77/423

1.54

0.99–2.37

1.97

0.04

0.00

0.62

0.13

DQB1*03:02

2

84/705

116/847

0.81

0.41–1.58

 − 0.62

0.53

12.83

0.28

 < 0.01

DQB1*04

4

307/940

346/1310

1.20

0.98–1.46

1.77

0.08

0.00

0.57

0.84

DQB1*04:02

3

75/823

99/1227

1.11

0.8–1.54

0.64

0.52

0.00

0.62

0.46

DQB1*05

4

284/940

316/1310

1.16

0.91–1.49

1.21

0.23

17.84

0.30

0.20

DQB1*05:01

3

174/823

161/1227

1.41

0.71–2.8

0.97

0.33

80.07

0.01

0.26

DQB1*05:02

2

28/705

48/847

0.69

0.42–1.11

 − 1.54

0.13

0.00

0.53

 < 0.01

DQB1*05:03

2

40/705

72/847

0.86

0.22–3.36

 − 0.22

0.82

30.15

0.23

 < 0.01

DQB1*06

5

443/952

645/1317

0.78

0.47–1.31

 − 0.93

0.35

73.20

0.00

0.63

DQB1*06:02

3

75/823

234/1227

0.42

0.31–0.56

 − 5.79

 < 0.001

0.00

0.62

0.68

DRB1*01

9

262/1480

185/1788

1.45

0.93–2.25

1.64

0.10

65.96

0.00

0.61

DRB1*03

5

102/535

88/705

1.33

0.71–2.49

0.88

0.38

69.81

0.01

0.28

DRB1*03:01

2

20/172

39/423

1.06

0.57–1.98

0.18

0.86

0.00

0.37

 < 0.01

DRB1*03:02

2

11/172

31/423

0.85

0.4–1.8

 − 0.43

0.67

0.00

0.74

 < 0.01

DRB1*04

6

360/1119

433/1179

0.92

0.77–1.11

 − 0.87

0.38

0.00

0.46

0.49

DRB1*04:01

3

7/756

21/897

0.41

0.17–0.95

 − 2.09

0.04

0.00

0.88

0.68

DRB1*04:03

2

28/702

39/854

0.72

0.24–2.18

 − 0.59

0.56

32.76

0.22

 < 0.01

DRB1*04:05

3

227/756

249/897

1.14

0.92–1.42

1.22

0.22

0.00

0.86

0.94

DRB1*04:06

2

42/702

58/854

0.84

0.37–1.9

 − 0.43

0.67

65.39

0.08

 < 0.01

DRB1*07

5

87/535

109/705

0.97

0.5–1.87

 − 0.09

0.93

73.62

0.00

0.34

DRB1*07:01

2

30/172

38/423

1.77

1.03–3.01

2.09

0.04

0.00

0.60

 < 0.01

DRB1*08

7

241/1237

257/1559

0.99

0.68–1.45

 − 0.04

0.97

37.63

0.14

0.27

DRB1*08:02

3

66/756

64/897

1.19

0.73–1.93

0.69

0.49

12.08

0.32

0.78

DRB1*08:03

2

8/105

3/93

2.82

0.78–10.13

1.59

0.11

0.00

0.91

 < 0.01

DRB1*09

6

180/1119

219/1179

0.95

0.76–1.19

 − 0.43

0.67

0.00

0.89

0.50

DRB1*10

3

18/300

9/242

1.67

0.74–3.81

1.23

0.22

0.00

0.98

0.27

DRB1*11

7

150/1237

146/1559

1.09

0.73–1.62

0.42

0.67

48.73

0.06

0.57

DRB1*11:01

3

45/823

72/1227

0.77

0.39–1.53

 − 0.74

0.46

50.22

0.13

0.18

DRB1*12

6

59/1119

68/1179

0.94

0.65–1.35

 − 0.36

0.72

0.00

0.79

0.22

DRB1*12:01

2

29/705

30/847

1.16

0.69–1.95

0.56

0.58

0.00

0.36

 < 0.01

DRB1*13

7

165/1237

196/1559

0.90

0.59–1.35

 − 0.52

0.60

57.24

0.02

0.22

DRB1*13:02

3

62/823

93/1227

0.93

0.6–1.42

 − 0.35

0.73

9.24

0.33

0.23

DRB1*14

4

18/351

24/292

0.67

0.35–1.29

 − 1.19

0.23

0.00

0.39

0.63

DRB1*15

8

177/1249

272/1566

0.72

0.47–1.1

 − 1.53

0.13

61.51

0.01

0.57

DRB1*15:01

4

78/874

193/1277

0.49

0.37–0.65

 − 4.97

 < 0.001

0.00

0.44

0.85

DRB1*15:02

2

21/63

15/57

1.2

0.49–2.92

0.41

0.67

0.00

0.63

 < 0.01

DRB1*16

5

27/1002

28/1096

0.95

0.54–1.66

 − 0.19

0.85

0.00

0.45

0.14

DRB1*16:02

3

12/756

18/897

0.90

0.25–3.23

 − 0.17

0.87

20.96

0.26

 < 0.01

HLA-G 14-bpD/I

2

63/86

76/101

0.90

0.47–1.74

 − 0.31

0.76

0.00

0.44

 < 0.01

Back to article page

Virology Journal

ISSN: 1743-422X