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Table 2 Association of HLA alleles and HTLV infection

From: The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis

 

#study

HTLV

Controls

OR

95% CI

z

P

I2 (%)

P-het

P-egger

A*02

3

202/569

130/318

0.86

0.63–1.15

 − 1.02

0.31

0.00

0.78

0.96

A*24

2

263/428

145/228

1.06

0.74–1.51

0.30

0.77

0.00

0.94

 < 0.01

A*30

3

22/569

24/318

0.75

0.39–1.45

 − 0.85

0.40

0.00

0.53

0.33

A*31

2

86/428

31/228

1.48

0.93–2.37

1.63

0.10

0.00

0.52

 < 0.01

B*13

2

13/428

9/228

1.48

0.52–4.16

0.74

0.46

0.00

0.49

 < 0.01

B*15

2

65/428

42/228

0.74

0.47–1.16

 − 1.32

0.19

0.00

0.36

 < 0.01

B*35

2

61/428

47/228

0.63

0.41–0.99

 − 2.01

0.05

0.00

0.49

 < 0.01

B*40:01

2

53/428

29/228

0.97

0.58–1.62

 − 0.12

0.90

0.00

0.41

 < 0.01

B*46

2

45/428

13/228

2.24

0.7–7.16

1.36

0.17

23.19

0.25

 < 0.01

B*51

2

74/428

32/228

1.23

0.76–1.98

0.85

0.40

0.00

0.53

 < 0.01

B*52

2

72/428

34/228

1.86

0.24–14.56

0.59

0.56

62.30

0.10

 < 0.01

C*01

2

173/428

66/228

1.28

0.89–1.83

1.32

0.19

0.00

0.35

 < 0.01

C*03

2

227/428

139/228

0.93

0.66–1.33

 − 0.38

0.70

0.00

0.72

 < 0.01

C*06

2

9/428

11/228

1.65

0.45–6.09

0.76

0.45

0.00

0.98

 < 0.01

C*08

2

87/565

40/265

1.3

0.39–4.37

0.43

0.67

79.08

0.02

 < 0.01

C*14

2

89/428

49/228

1.71

0.17–17.45

0.45

0.65

69.16

0.07

 < 0.01

C*15

2

9/428

8/228

1.41

0.44–4.56

0.57

0.57

0.00

0.45

 < 0.01

DRB1*01

3

33/263

26/235

1.21

0.7–2.1

0.68

0.50

0.00

0.97

0.44

DRB1*03

3

20/119

33/176

1.67

0.22–12.78

0.49

0.62

85.09

0.00

0.1

DRB1*04

4

96/267

80/288

0.77

0.25–2.34

 − 0.47

0.64

70.75

0.01

0.46

DRB1*07

3

13/119

25/176

0.91

0.33–2.48

 − 0.19

0.85

32.96

0.22

0.7

DRB1*08

3

44/263

45/235

0.81

0.5–1.31

 − 0.85

0.40

0.00

0.36

0.41

DRB1*09

4

34/267

56/288

0.57

0.34–0.94

 − 2.00

0.05

0.00

0.98

0.52

DRB1*10

2

3/115

4/123

0.79

0.17–3.63

 − 0.30

0.76

0.00

0.76

 < 0.01

DRB1*11

4

48/267

45/288

1.28

0.62–2.65

0.67

0.50

45.24

0.14

0.18

DRB1*12

3

16/263

19/235

0.74

0.34–1.6

 − 0.77

0.44

6.92

0.34

0.8

DRB1*13

3

42/263

47/235

0.79

0.49–1.28

 − 0.97

0.33

0.00

0.66

0.5

DRB1*14

4

32/267

68/288

0.76

0.45–1.29

 − 1.02

0.31

0.00

0.57

0.76

DRB1*15

4

81/267

66/288

1.28

0.56–2.92

0.58

0.57

64.47

0.03

0.72

DRB1*15:02

2

113/419

95/453

1.21

0.68–2.15

0.66

0.51

53.34

0.05

 < 0.01

DRB1*16

3

2/263

9/235

0.20

0.04–0.86

 − 1.97

0.05

0.00

0.84

0.51

G (SNI)

2

96/220

124/303

1.12

0.78–1.59

0.61

0.54

0.00

0.61

 < 0.01

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