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Fig. 8 | Virology Journal

Fig. 8

From: Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells

Fig. 8

Protein interaction network revealing core genes and GSEA enrichment analysis. (A) Protein–protein interaction network. The size of the nodes represents the importance of the genes in the protein interaction network, with larger nodes indicating proteins with more interaction partners. The top 20 core genes are labeled. (B) Heatmap of the top twenty core genes. The colors of the horizontal axis represent different sample groups. The depth of color in the heatmap represents the level of expression, with red indicating high gene expression and blue indicating low gene expression. (C-D) GSEA enrichment analysis plot. The x-axis represents the ranking of gene sets, with the ranking decreasing from left to right, whereas the y-axis represents the enrichment score. The enrichment score curve shows the degree of enrichment of a gene set during the PEDV infection process, with a larger absolute value of the curve peak indicating a greater degree of enrichment of the gene set during the PEDV infection process. (E) Bar plot of the fold change in core gene RNA-seq and qPCR expression. The y-axis shows the log2FoldChange, and the x-axis indicates the analyzed gene. Data are presented as the mean ± SD, n = 3

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Virology Journal

ISSN: 1743-422X