Fig. 7

Tissue sections of A LSIL (CIN I) Ectocervical epithelium showed increased lower one-third thickness proliferation with detected mid-epithelial mitotic figures (circles) and mild P16 positivity. B HSIL (CIN III) The epithelium showed full thickness atypical cellular proliferation and marked P16 positivity. C Squamous cell carcinoma (SCC). Surface dysplastic epithelium with infiltrating squamous nests with high proliferation and marked P16 positivity. D Adenocarcinoma. Infiltrating cribriform fused irregular glands with high proliferation and marked P16 positivity (H&E stain, Ki-67 and P16 immune stains, 10x, 20x, and 40x original magnifications)