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Table 4 Predictive values of single and combined variables for non-severe cases (n = 356)

From: The role of hematological parameters in asymptomatic and non-severe cases of Omicron variant infection

Characteristic variables

AUC

Cut off values*

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Accuracy (%)

 + LR

-LR

Variable P

Single variable

 PLT

0.648

 ≤ 208

67.14

59.44

71.14

54.84

64.04

1.66

0.55

 < 0.001

 Normalized Lym

0.766

 ≤ -0.20

62.91

76.92

80.24

58.20

68.54

2.73

0.48

 < 0.001

 MO

0.570

 > 0.53

44.60

70.63

69.34

46.12

55.06

1.52

0.78

0.024

 EOS

0.748

 ≤ 0.02

60.09

78.32

80.50

56.85

67.42

2.77

0.51

 < 0.001

 Normalized BAS

0.760

 ≤ -0.38

79.81

64.34

76.92

68.15

73.60

2.24

0.31

 < 0.001

 Lym (%)

0.659

 ≤ 22.30

67.61

57.34

70.24

54.31

63.48

1.58

0.56

 < 0.001

 Monocytes (%)

0.694

 > 6.50

71.36

62.94

74.15

59.60

67.98

1.93

0.46

 < 0.001

 EOS(%)

0.720

 ≤ 0.40

60.56

74.13

77.71

55.79

66.01

2.34

0.53

 < 0.001

 BAS(%)

0.736

 ≤ 0.10

56.34

79.72

80.54

55.08

65.73

2.78

0.55

 < 0.001

 NLR

0.652

 > 3.99

52.58

72.73

74.17

50.73

60.67

1.93

0.65

 < 0.001

 Normalized PLR

0.696

 > -0.13

52.11

85.31

84.09

54.46

65.45

3.55

0.56

 < 0.001

Combined variables

 Lym + EOS

0.780

-

68.08

75.52

80.55

61.37

71.07

2.78

0.42

 > 0.05*

 Lym + BAS

0.802

-

76.53

71.33

79.90

67.11

74.44

2.67

0.33

 < 0.05*

 PLR + BAS

0.804

-

83.57

63.64

77.39

72.23

75.56

2.3

0.26

 < 0.01*

 EOS + BAS

0.787

-

84.98

60.84

76.37

73.12

75.28

2.17

0.25

0.013#

 BAS% + MO%

0.805

-

79.34

71.33

80.48

69.86

76.12

2.77

0.29

 < 0.01*

 Lym + MO%

0.810

-

65.26

83.92

85.81

61.86

72.75

4.06

0.41

 ≤ 0.01*

 BAS + MO%

0.810

-

84.51

67.13

79.29

74.42

77.53

2.57

0.23

 < 0.01*

  1. The cutoff values were selected by Youden Index
  2. Lym Lymphocytes, BAS Basophils, EOS Eosinophils, MO Monocytes, PLT Platelets, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, AUC area under the curve, PPV positive predictive values, NPV negative predictive values, + LR positive likelihood ratios, -LR negative likelihood ratios
  3. *compared with the AUC of each corresponding single variable
  4. #compared with the AUC of BAS