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Fig. 4 | Virology Journal

Fig. 4

From: Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG

Fig. 4

Neutralization profiles for subtype G versus CRF02_AG using individual NmAbs. NmAbs targeting the A) MPER, B) V3, C) V1V2, D) CD4bs and E) bridging regions and gp120 glycan were tested against individual PSV and the IC50 values graphed. Statistical differences between Subtype G and CRF02_AG PSV were determined using Mann Whitney U Test; * = p<0.05, ** = p<0.005, *** = p<0.0005, as indicated. F The NmAb GM IC50 was determined for all subtype G and CRF02_AG PSV and plotted to reflect relative NmAb potencies and differences between HIV subtype G and CRF02_AG. The dotted and dashed lines indicate NmAb neutralization potency of GM IC50 = 1 μg/ml or 10 μg/ml, respectively. NmAbs shown in red are potently neutralizing against both subtype G and CRF02_AG; NmAbs shown in yellow were weakly neutralizing against both

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Virology Journal

ISSN: 1743-422X