Table 1 Patient characteristics

Patients, n

29

10

19

Age, median (range)

35 (11–63)

43.5 (25–61)

34 (11–63)

0.581

Sex, n (%)

0.494

 Male

17 (58.6%)

5 (50%)

12 (63.2%)

 Female

12 (41.4%)

5 (50%)

7 (36.8%)

Diagnosis (%)

0.093

 ALL

10 (34.5%)

1 (10.0%)

9 (47.4%)

 AML

10 (34.5%)

6 (60.0%)

4 (21.1%)

 MDS

4 (13.8%)

2 (20.0%)

2 (10.4%)

 Others

5 (17.2%)

1 (10.0%)

4 (21.1%)

Disease status, n (%)

0.044

 CR1

19 (65.5%)

9 (90.0%)

10 (52.6%)

 ≥CR2

10 (34.5%)

1 (10.0%)

9 (47.4%)

Transplant graft, n (%)

0.127

 BM + PBSC

5 (17.2%)

0

5 (26.3%)

 PBSC

21 (72.4%)

8 (80.0%)

13 (68.4%)

 Other

3 (10.4%)

2 (20.0%)

1 (5.3%)

Donor–recipient gender match, n (%)

0.619

 Male–male

9 (31.0%)

4 (40.0%)

5 (26.3%)

 Male–female

8 (27.6%)

3 (30.0%)

5 (26.3%)

 Female–male

7 (24.1%)

1 (10.0%)

6 (31.6%)

 Female–female

4 (13.8%)

2 (20.0%)

2 (10.5%)

 Other (only cord blood infused)

1 (3.4%)

0

1 (5.3%)

Number of HLA-A, B, DR mismatches, n (%)

0.568

 1

1 (3.4%)

0

1 (5.3%)

 2

1 (3.4%)

0

1 (5.3%)

 3

27 (93.1%)

10 (100%)

17 (89.5%)

Donor-recipient relationship,

n (%)

0.747

 Father-child

10 (34.5%)

3 (30.0%)

7 (36.8%)

 Mother-child

5 (17.2%)

1 (10.0%)

4 (21.1%)

 Sibling-sibling

6 (20.7%)

3 (30.0%)

3 (15.8%)

 Child-parent

7 (24.1%)

3 (30.0%)

4 (21.1%)

 Other

1 (3.4%)

0

1 (5.3%)

Infused cell dose, median (range)

 MNC (× 10⁸/kg)

9.76 (5.56–17.72)

12.43 (7.46–17.72)

8.70 (5.56–15.61)

0.009

 CD34⁺ cells (× 10⁶/kg)

3.23 (1.21–7.43)

3.10 (1.21–7.09)

4.16 (1.38–7.43)

0.890

Engraftment (yes or no), n (%)

 Neutrophils

29 (100%)

10 (100%)

19 (100%)

NS

 Platelets

21 (72.4%)

8 (80.0%)

13 (68.4%)

0.507

Acute GVHD prior to ADV pneumonia, n (%)

0.564

 None

18 (62.1%)

6 (60.0%)

12 (63.2%)

 Grade I

6 (20.7%)

3 (30.0%)

3 (15.7%)

 Grade II-IV

5 (17.2%)

1 (10.0%)

4 (21.1%)

Chronic GVHD prior to pneumonia, n (%)

0.181

 Total

7 (24.1%)

4 (40.0%)

3 (15.8%)

 Clinical extensive

4 (13.8%)

3 (30.0%)

1 (5.3%)