Table 2 Clinical characteristics of 50 children with PVB19 infection after SOT or HSCT
From: Distinct clinical features of transplanted children with Parvovirus B19 infection
All patients (n = 50) | SOT patients (n = 31) | HSCT patients (n = 19) | P value | |
|---|---|---|---|---|
Age of transplant, years | 8(3 ∼ 11) | 9(3 ∼ 11) | 8(4 ∼ 13) | |
No. of male/female | 39/11 | 22/9 | 17/2 | 0.302 |
First B19 DNA-positive detection, weeks post transplantation | 14(5 ∼ 47) | 10(4 ∼ 136) | 14(9 ∼ 28) | 0.613 |
PVB19 IgM positive during the disease course | 13(26.0%) | 11(35.5%) | 2(10.5%) | 0.105 |
PVB19 IgG positive during the disease course | 12(24.0%) | 10(32.3%) | 2(10.5%) | 0.160 |
Maximum viral load in the blood, copies/ml | 9.74 × 107(4.75 × 104∼1.19 × 1010) | 5.28 × 104(8.01 × 103∼4.74 × 107) | 1.40 × 1010(7.26 × 109∼4.21 × 1010) | 0.001 |
Anemia | 50(100.0%) | 31(100.0%) | 19(100.0%) | 1.000 |
Lowest HGB during B19 DNA positive, g/L | 68(54 ∼ 82) | 78(58 ∼ 89) | 58(54 ∼ 67) | 0.012 |
Leukopenia | 20(40.0%) | 10(32.3%) | 10(52.6%) | 0.258 |
Lowest WBC count, ×109/L | 3.2(2.4 ∼ 4.9) | 3.7(2 ∼ 4.9) | 2.9(3 ∼ 3.6) | 0.147 |
Thrombopenia | 18(36.0%) | 6(19.4%) | 12(63.2%) | 0.005 |
Lowest PLT count, ×109/L | 73(57 ∼ 168) | 94(63 ∼ 176) | 47(31 ∼ 58) | 0.026 |
Pancytopenia | 10(20.0%) | 4(12.9%) | 6(31.6%) | 0.216 |
Graft dysfunction at disease onset | 18(36.0%) | 5(16.1%) | 13(68.4%) | < 0.001 |