Table 3 Outcomes by consecutive epidemic waves using descriptive statistics

Hospital mortality

107 (14.8%)

30 (16.6%)

54 (15.6%)

23 (11.9%)

0.378

Complications

 Acute respiratory distress syndrome

149 (20.6%)

29 (16.0%)

72 (20.7%)

48 (24.7%)

0.005

 Multi-organ failure

38 (5.3%)

5 (2.8%)

17 (4.9%)

16 (8.2%)

0.014

 Septic shock

46 (6.4%)

12 (6.6%)

25 (7.2%)

9 (4.6%)

0.034

 Severe acute kidney injury

115 (15.9%)

16 (8.8%)

62 (17.9%)

37 (19.1%)

0.013

 Myocarditis

3 (0.4%)

2 (1.1%)

1 (0.3%)

0 (0.0%)

0.170

 Arrhythmia

96 (13.3%)

26 (14.4%)

46 (13.3%)

24 (12.4%)

0.847

 Pneumothorax

17 (2.4%)

1 (0.6%)

9 (2.6%)

7 (3.6%)

0.140

 COVID-19 associated pulmonary aspergillosis

22 (3.0%)

7 (3.9%)

5 (1.4%)

10 (5.2%)

0.052

 Thromboembolic disease (including ischemic stroke)

59 (8.2%)

8 (4.4%)

28 (8.1%)

23 (11.9%)

0.003

 Hospital acquired pneumonia / ventilator associated pneumonia

129 (17.9%)

23 (12.7%)

61 (17.6%)

45 (23.2%)

0.029

 Bloodstream infection

56 (7.8%)

17 (9.4%)

24 (6.9%)

15 (7.7%)

0.393

 Neurological sequelae (non-stroke)

92 (12.7%)

24 (13.3%)

44 (12.7%)

24 (12.4%)

0.027

 Bleeding

47 (6.5%)

2 (1.1%)

32 (9.2%)

13 (6.7%)

< 0.001

Median [IQR]

Median [IQR]

Median [IQR]

Median [IQR]

p

Length of hospital stay (days)

9 (5–19)

9 (5–21)

10 (5–18)

8 (4–20)

0.476

 Intensive care unit patients (days)

27 (15.5–46.5)

33 (18–56)

22 (14–43)

32 (18–50)

0.025

Length of intensive care unit stay (days)

18 (8–37)

18 (12–35)

15 (6–34)

25 (11–47)

0.040

Time to intensive care unit (days)

0 (0–2)

1 (0–3)

0 (0–3)

0 (0–1)

0.015

 Non-transferred patients (days)

1 (0–4)

2 (1–4)

1 (0–5)

1 (0–3)

0.222

Time to death (days)

15 (7–28)

12 (6–22)

15 (8–28)

18 (8–43)

0.340

 Normal ward (days)

8 (5–14.25)

8 (5–15)

8 (4–11)

8 (5–15)

0.667

 Intensive care unit (days)

20 (13.5–38)

21 (11–30)

19 (14–31)

21 (17–44)

0.724